Across TCGA patient cohorts, HLA-H mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-H-associated genes across cancer lineages are GACAT1, SDAD1P4, and SULT1D1P. Each is linked with HLA-H in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-H-to-partner and partner-to-HLA-H results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-H→partner) and Y-score (partner→HLA-H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GACAT1 →	+0.082	+5.513	<.001	.004	3	2
SKCM	SDAD1P4 →	+0.053	+5.159	<.001	.007	3	1
SKCM	SULT1D1P →	+0.051	+4.979	<.001	.009	3	1
SKCM	TUBBP11 →	+0.233	+4.979	<.001	.009	3	1
SKCM	C5orf66-AS2 →	+0.028	+5.362	<.001	.005	3	1
SKCM	RN7SL680P →	+0.380	+7.219	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

HLA-H survival (RNA) · tumor vs normal (RNA) · all HLA-H data types