Across TCGA cell cohorts, HLA-H protein abundance is significantly associated with the go_rna of many other GO terms, with 1,640 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLA-H-associated GO terms across cancer lineages are Antigen processing and presentation of exogenous peptide antigen via MHC class Ib, Antigen processing and presentation of endogenous peptide antigen via MHC class I, and Antigen processing and presentation of endogenous peptide antigen. Each is linked with HLA-H in more than 7 cancer types. Because this analysis shows association rather than direction, both HLA-H-to-partner and partner-to-HLA-H results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-H→partner) and Y-score (partner→HLA-H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.295	+2.915	<.001	<.001	3	8
BREAST	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.398	+3.061	<.001	<.001	3	8
BREAST	Antigen processing and presentation of endogenous peptide antigen →	+0.383	+2.854	<.001	<.001	3	6
BREAST	Regulation of T cell anergy →	+0.312	+2.534	<.001	.003	3	6
BREAST	Regulation of lymphocyte anergy →	+0.312	+2.534	<.001	.003	3	6
BLOOD_Myeloma	Negative regulation of leukocyte apoptotic process →	+0.141	+1.484	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,640 associations by consensus.

Exploration

HLA-H survival (RNA) · tumor vs normal (RNA) · all HLA-H data types