Across TCGA patient cohorts, HLA-F mutation is significantly associated with the RNA expression of many other genes, with 1,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-F-associated genes across cancer lineages are RNU5E-9P, TRAJ12, and FAM74A1. Each is linked with HLA-F in more than 2 cancer types. Because this analysis shows association rather than direction, both HLA-F-to-partner and partner-to-HLA-F results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-F→partner) and Y-score (partner→HLA-F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU5E-9P →	+0.178	+3.807	<.001	.001	3	3
CESC	TRAJ12 →	+0.900	+4.608	<.001	.001	3	2
HNSC	FAM74A1 →	+0.185	+7.357	<.001	<.001	3	2
CESC	LINC02378 →	+0.042	+4.345	<.001	.002	3	2
BRCA	SRIP2 →	+0.311	+5.683	<.001	.004	3	2
BRCA	RNU7-56P →	+0.649	+5.148	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,155 associations by consensus.

Exploration

HLA-F survival (RNA) · tumor vs normal (RNA) · all HLA-F data types