Across TCGA patient cohorts, HLA-F mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-F-associated genes across cancer lineages are PKC-a_pS657, c-Met_pY1235, and FoxM1. Each is linked with HLA-F in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-F-to-partner and partner-to-HLA-F results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-F→partner) and Y-score (partner→HLA-F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-a_pS657 →	-0.391	-3.160	.019	.019	3	2
UCEC	c-Met_pY1235 →	+0.069	+2.807	.033	.003	3	2
UCEC	FoxM1 →	+0.264	+3.009	.019	.019	3	1
UCEC	p27_pT198 →	+0.128	+3.321	.006	.010	3	1
UCEC	PDCD4 →	-0.453	-3.169	.027	.018	3	1
UCEC	PKC-delta_pS664 →	-0.117	-2.312	.026	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

HLA-F survival (RNA) · tumor vs normal (RNA) · all HLA-F data types