Across TCGA patient cohorts, HLA-E RNA expression is significantly associated with the protein abundance of many other proteins, with 16,922 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-E-associated proteins across cancer lineages are UBE2L6, PSMB10, and GBP1. Each is linked with HLA-E in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-E-to-partner and partner-to-HLA-E results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-E→partner) and Y-score (partner→HLA-E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBE2L6 →	+0.629	+0.658	<.001	<.001	3	10
LSCC	PSMB10 →	+0.604	+0.721	<.001	<.001	3	10
HNSC	GBP1 →	+1.084	+0.809	<.001	.007	3	10
HNSC	GBP4 →	+0.740	+0.652	<.001	.004	3	10
GBM	HLA-DPB1 →	+0.674	+0.658	.003	.002	3	10
HNSC	IFIT3 →	+1.382	+0.896	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,922 associations by consensus.

Exploration

HLA-E survival (RNA) · tumor vs normal (RNA) · all HLA-E data types