Across TCGA patient cohorts, HLA-E protein abundance is significantly associated with the protein abundance of many other proteins, with 16,588 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HLA-E-associated proteins across cancer lineages are STAT1, TAP1, and HLA-F. Each is linked with HLA-E in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-E-to-partner and partner-to-HLA-E results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-E→partner) and Y-score (partner→HLA-E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAT1 →	+0.649	+0.489	<.001	<.001	3	10
UCEC	TAP1 →	+0.761	+0.497	<.001	<.001	3	10
HNSC	HLA-F →	+0.778	+0.437	<.001	<.001	3	10
BRCA	ITGAL →	+0.692	+0.450	<.001	<.001	3	10
UCEC	CYBB →	+0.757	+0.468	<.001	<.001	3	10
OV	GBP4 →	+0.745	+0.546	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,588 associations by consensus.

Exploration

HLA-E survival (RNA) · tumor vs normal (RNA) · all HLA-E data types