Across TCGA patient cohorts, HLA-E mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-E-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK_pT183_Y185, and Bak. Each is linked with HLA-E in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-E-to-partner and partner-to-HLA-E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-E→partner) and Y-score (partner→HLA-E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.145	-2.990	.034	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-3.156	.031	.020	3	1
UCEC	Bak →	+0.332	+3.169	.015	.020	3	1
UCEC	4E-BP1_pT37_T46 →	-0.559	-3.169	.006	.020	3	1
UCEC	c-Met_pY1235 →	+0.084	+3.009	.040	.019	3	1
UCEC	EGFR_pY1068 →	-0.304	-3.169	.027	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

HLA-E survival (RNA) · tumor vs normal (RNA) · all HLA-E data types