Across TCGA patient cohorts, HLA-DRB9 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,954 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HLA-DRB9-associated proteins across cancer lineages are PARVG, TRIM21, and GMIP. Each is linked with HLA-DRB9 in more than 4 cancer types. Because this analysis shows association rather than direction, both HLA-DRB9-to-partner and partner-to-HLA-DRB9 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB9→partner) and Y-score (partner→HLA-DRB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PARVG →	+0.402	+0.389	<.001	<.001	3	4
GBM	TRIM21 →	+0.340	+0.440	.002	.001	2	5
CCRCC	GMIP →	+0.313	+0.535	<.001	.001	3	4
GBM	ALOX5 →	+0.550	+0.430	.001	<.001	3	4
OV	HLA-DRA →	+0.788	+0.473	.004	.008	2	5
GBM	LCP1 →	+0.686	+0.395	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,954 associations by consensus.

Exploration

HLA-DRB9 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB9 data types