Across TCGA patient cohorts, HLA-DRB9 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DRB9-associated genes across cancer lineages are CACNA1C-IT1, MIR96, and RNU6-1325P. Each is linked with HLA-DRB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DRB9-to-partner and partner-to-HLA-DRB9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB9→partner) and Y-score (partner→HLA-DRB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CACNA1C-IT1 →	+0.137	+5.097	<.001	.008	3	2
HNSC	MIR96 →	+0.393	+7.954	<.001	.008	3	1
HNSC	RNU6-1325P →	+0.338	+7.954	<.001	.008	3	1
HNSC	MIR512-2 →	+0.328	+7.954	<.001	.008	3	1
HNSC	MIR509-1 →	+0.338	+7.954	<.001	.008	3	1
HNSC	MIR509-3 →	+0.408	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

HLA-DRB9 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB9 data types