Across TCGA cell cohorts, HLA-DRB4 protein abundance is significantly associated with the RNA expression of many other genes, with 291 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLA-DRB4-associated genes across cancer lineages are HOXA1, UST, and NEIL2. Each is linked with HLA-DRB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DRB4-to-partner and partner-to-HLA-DRB4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB4→partner) and Y-score (partner→HLA-DRB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HOXA1 →	-1.059	-1.987	.009	.005	3	2
BLOOD_Lymphoma	UST →	+2.949	+1.282	.006	.001	3	2
BLOOD_Lymphoma	NEIL2 →	+1.442	+1.708	<.001	.001	3	2
BLOOD_Lymphoma	HLA-DRB1 →	+2.004	+1.592	<.001	.003	3	2
BLOOD_Lymphoma	HLA-DPB1 →	+1.715	+1.634	<.001	.002	3	2
BLOOD_Lymphoma	BORCS8 →	-1.037	-1.924	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 291 associations by consensus.

Exploration

HLA-DRB4 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB4 data types