Across TCGA patient cohorts, HLA-DRB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,151 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DRB1-associated proteins across cancer lineages are LCP2, ARHGEF6, and DOCK10. Each is linked with HLA-DRB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DRB1-to-partner and partner-to-HLA-DRB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB1→partner) and Y-score (partner→HLA-DRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCP2 →	+0.609	+1.377	<.001	<.001	3	10
OV	ARHGEF6 →	+0.439	+1.461	<.001	<.001	3	10
UCEC	DOCK10 →	+0.522	+1.177	<.001	.008	3	10
GBM	HLA-DPA1 →	+0.918	+1.189	<.001	<.001	3	10
GBM	HLA-DPB1 →	+0.824	+1.174	<.001	<.001	3	10
GBM	HLA-DRA →	+1.101	+1.314	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,151 associations by consensus.

Exploration

HLA-DRB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB1 data types