Across TCGA patient cohorts, HLA-DRB1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HLA-DRB1-associated genes across cancer lineages are TSPY4, RGS21, and SLC16A12-AS1. Each is linked with HLA-DRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DRB1-to-partner and partner-to-HLA-DRB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB1→partner) and Y-score (partner→HLA-DRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	TSPY4 →	+1.475	+4.039	<.001	.009	3	1
SCLC	RGS21 →	+0.066	+3.693	<.001	.006	3	1
SKCM	SLC16A12-AS1 →	+0.070	+6.469	<.001	.001	3	1
SKCM	NCKAP1P1 →	+0.033	+4.979	<.001	.009	3	1
SKCM	MIR6882 →	+0.551	+5.680	<.001	.003	3	1
SKCM	MIR2276 →	+0.440	+5.680	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HLA-DRB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB1 data types