Across TCGA patient cohorts, HLA-DRB1 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible HLA-DRB1-associated genes across cancer lineages are CD8+ T-cells and CMP. Each is linked with HLA-DRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DRB1-to-partner and partner-to-HLA-DRB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB1→partner) and Y-score (partner→HLA-DRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CD8+ T-cells →	+0.058	+3.074	.020	.033	3	1
SCLC	CMP →	+0.083	+2.839	.002	.049	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

HLA-DRB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB1 data types