Across TCGA cell cohorts, HLA-DRB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,497 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DRB1-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, and Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Each is linked with HLA-DRB1 in more than 19 cancer types. Because this analysis shows association rather than direction, both HLA-DRB1-to-partner and partner-to-HLA-DRB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB1→partner) and Y-score (partner→HLA-DRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Dendritic cell antigen processing and presentation →	+1.860	+5.971	<.001	<.001	3	20
BLOOD_Leukemia	Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+2.022	+5.967	<.001	<.001	3	16
BLOOD_Leukemia	Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.932	+5.967	<.001	<.001	3	16
LUNG_NSCLC_LUSC	MHC protein complex assembly →	-0.307	-3.725	<.001	<.001	3	16
LUNG_NSCLC_LUSC	MHC class II protein complex assembly →	-0.495	-3.013	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Peptide antigen assembly with MHC protein complex →	-0.307	-3.725	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,497 associations by consensus.

Exploration

HLA-DRB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB1 data types