Across TCGA patient cohorts, HLA-DQB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,897 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HLA-DQB3-associated GO terms across cancer lineages are Aerobic respiration, Cytoplasmic pattern recognition receptor signaling pathway, and Peptidyl-lysine deacetylation. Each is linked with HLA-DQB3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HLA-DQB3-to-partner and partner-to-HLA-DQB3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB3→partner) and Y-score (partner→HLA-DQB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Aerobic respiration →	+0.183	+0.054	<.001	.005	2	6
ESCA	Cytoplasmic pattern recognition receptor signaling pathway →	+0.157	+0.060	<.001	<.001	3	5
STAD	Peptidyl-lysine deacetylation →	+0.058	+0.047	<.001	.003	3	5
ESCA	Cellular respiration →	+0.176	+0.034	<.001	.001	3	5
ESCA	Protein polymerization →	+0.146	+0.031	<.001	.002	3	4
ESCA	Oxidative phosphorylation →	+0.184	+0.054	<.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,897 associations by consensus.

Exploration

HLA-DQB3 survival (RNA) · tumor vs normal (RNA) · all HLA-DQB3 data types