Across TCGA pan-cancer cohorts, HLA-DQA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HLA-DQA1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HLA-DQA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-DQA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where HLA-DQA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.683	1.000	.027	9	view →
HNSC	OS	Tertile	All	0.827	0.644	.019	8	view →
LSCC	DFS	Median	II,III,IV	0.505	0.877	.001	8	view →
LUAD	OS	Quartile	All	0.773	0.944	.020	7	view →
UCEC	OS	Median	III,IV	0.807	0.333	.042	4	view →
PDAC	OS	Quartile	III,IV	0.391	0.690	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: HLA-DQA1 tumor-vs-normal RNA expression · all HLA-DQA1 data types