HLA-DQA1

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, HLA-DQA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,215 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DQA1-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, and Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Each is linked with HLA-DQA1 in more than 13 cancer types. Because this analysis shows association rather than direction, both HLA-DQA1-to-partner and partner-to-HLA-DQA1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQA1→partner) and Y-score (partner→HLA-DQA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CNSDendritic cell antigen processing and presentation →+1.738+1.968<.001<.001314
BLOOD_LeukemiaRegulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →+1.904+4.115<.001<.001311
BLOOD_LeukemiaPositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →+1.820+4.115<.001<.001311
LUNG_NSCLC_LUSCMHC class II protein complex assembly →-0.534-0.315<.001.003311
LUNG_NSCLC_LUSCPeptide antigen assembly with MHC class II protein complex →-0.534-0.315<.001.003311
BLOOD_LeukemiaAntigen processing and presentation of endogenous peptide antigen →+0.203+3.092<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,215 associations by consensus.

Exploration