Across TCGA patient cohorts, HLA-DPB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,909 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DPB1-associated proteins across cancer lineages are PTPN6, RASAL3, and WAS. Each is linked with HLA-DPB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DPB1-to-partner and partner-to-HLA-DPB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPB1→partner) and Y-score (partner→HLA-DPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PTPN6 →	+0.613	+1.215	<.001	<.001	3	10
OV	RASAL3 →	+0.576	+1.374	<.001	<.001	3	10
GBM	WAS →	+0.700	+1.293	<.001	<.001	3	10
OV	WIPF1 →	+0.498	+1.202	<.001	<.001	3	10
HNSC	SASH3 →	+0.638	+1.482	<.001	<.001	3	10
HNSC	ITGAL →	+0.670	+1.013	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,909 associations by consensus.

Exploration

HLA-DPB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DPB1 data types