Across TCGA patient cohorts, HLA-DPB1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,084 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DPB1-associated genes across cancer lineages are RASAL3, ABI3, and BIN2. Each is linked with HLA-DPB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DPB1-to-partner and partner-to-HLA-DPB1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPB1→partner) and Y-score (partner→HLA-DPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RASAL3 →	+0.944	+0.562	<.001	<.001	3	10
UCEC	ABI3 →	+0.980	+0.748	<.001	<.001	3	10
OV	BIN2 →	+0.926	+0.581	<.001	.001	3	10
HNSC	ITK →	+1.284	+0.563	<.001	<.001	3	10
HNSC	CD2 →	+1.562	+0.549	<.001	<.001	3	10
HNSC	CD48 →	+1.131	+0.503	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,084 associations by consensus.

Exploration

HLA-DPB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DPB1 data types