Across TCGA patient cohorts, HLA-DPB1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DPB1-associated genes across cancer lineages are PCNA, EGFR_pY1068, and A-Raf_pS299. Each is linked with HLA-DPB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HLA-DPB1-to-partner and partner-to-HLA-DPB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPB1→partner) and Y-score (partner→HLA-DPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.270	+3.169	.007	.019	2	3
UCEC	EGFR_pY1068 →	-0.300	-3.321	.010	.009	3	1
UCEC	A-Raf_pS299 →	-0.156	-3.584	.005	.002	3	1
UCEC	ACC1 →	+0.379	+2.820	.025	.035	3	1
UCEC	mTOR_pS2448 →	-0.211	-3.302	.002	.010	3	1
UCEC	p70-S6K_pT389 →	-0.217	-2.584	.014	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

HLA-DPB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DPB1 data types