Across TCGA cell cohorts, HLA-DPB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,027 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DPB1-associated GO terms across cancer lineages are MHC class II protein complex assembly, Peptide antigen assembly with MHC class II protein complex, and MHC protein complex assembly. Each is linked with HLA-DPB1 in more than 13 cancer types. Because this analysis shows association rather than direction, both HLA-DPB1-to-partner and partner-to-HLA-DPB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPB1→partner) and Y-score (partner→HLA-DPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MHC class II protein complex assembly →	-0.416	-3.621	<.001	<.001	3	14
BONE	Peptide antigen assembly with MHC class II protein complex →	-0.416	-3.621	<.001	<.001	3	14
LIVER	MHC protein complex assembly →	-0.223	-2.469	<.001	<.001	3	13
LIVER	Peptide antigen assembly with MHC protein complex →	-0.223	-2.469	<.001	<.001	3	13
BLOOD_Leukemia	Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.900	+5.703	<.001	<.001	3	11
BLOOD_Leukemia	Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.815	+5.703	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,027 associations by consensus.

Exploration

HLA-DPB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DPB1 data types