Across TCGA patient cohorts, HLA-DMA RNA expression is significantly associated with the protein abundance of many other proteins, with 23,240 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DMA-associated proteins across cancer lineages are UBA7, PLCB2, and PSMB5. Each is linked with HLA-DMA in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DMA-to-partner and partner-to-HLA-DMA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DMA→partner) and Y-score (partner→HLA-DMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBA7 →	+0.474	+0.950	<.001	<.001	3	10
GBM	PLCB2 →	+0.675	+1.190	<.001	<.001	3	10
OV	PSMB5 →	-0.609	-1.364	<.001	<.001	3	10
HNSC	CD74 →	+1.112	+1.766	<.001	<.001	3	10
GBM	HLA-DPA1 →	+0.939	+0.903	<.001	<.001	3	10
OV	HLA-DPB1 →	+0.826	+1.150	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,240 associations by consensus.

Exploration

HLA-DMA survival (RNA) · tumor vs normal (RNA) · all HLA-DMA data types