Across TCGA patient cohorts, HLA-DMA mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DMA-associated genes across cancer lineages are ATM, FoxM1, and JNK2. Each is linked with HLA-DMA in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DMA-to-partner and partner-to-HLA-DMA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DMA→partner) and Y-score (partner→HLA-DMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.493	-2.986	.015	.035	3	2
UCEC	FoxM1 →	+0.339	+2.700	.003	.006	3	1
UCEC	JNK2 →	+0.236	+3.009	.008	.019	3	1
UCEC	Ku80 →	+0.313	+2.013	.003	.018	3	1
UCEC	MEK1 →	+0.447	+2.000	.006	.030	3	1
UCEC	p62 Lck ligand →	+0.517	+3.169	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

HLA-DMA survival (RNA) · tumor vs normal (RNA) · all HLA-DMA data types