Across TCGA cell cohorts, HLA-DMA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,929 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DMA-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, MHC class II protein complex assembly, and Peptide antigen assembly with MHC class II protein complex. Each is linked with HLA-DMA in more than 14 cancer types. Because this analysis shows association rather than direction, both HLA-DMA-to-partner and partner-to-HLA-DMA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DMA→partner) and Y-score (partner→HLA-DMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Dendritic cell antigen processing and presentation →	+1.655	+3.254	<.001	<.001	3	15
LUNG_NSCLC_LUSC	MHC class II protein complex assembly →	-0.482	-2.041	<.001	.002	3	15
LUNG_NSCLC_LUSC	Peptide antigen assembly with MHC class II protein complex →	-0.482	-2.041	<.001	.002	3	15
BLOOD_Myeloma	Positive regulation of dendritic cell antigen processing and presentation →	+1.499	+2.765	<.001	<.001	3	14
PANCREAS	Regulation of antigen processing and presentation →	+0.241	+1.973	<.001	<.001	3	13
BREAST	Positive regulation of CD8-positive, alpha-beta T cell proliferation →	+0.228	+1.625	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,929 associations by consensus.

Exploration

HLA-DMA survival (RNA) · tumor vs normal (RNA) · all HLA-DMA data types