Across TCGA cell cohorts, HLA-DMA mutation is significantly associated with the mutation status of many other genes, with 466 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HLA-DMA-associated genes across cancer lineages are ZNF568, ZNF737, and LY75-CD302. Each is linked with HLA-DMA in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DMA-to-partner and partner-to-HLA-DMA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DMA→partner) and Y-score (partner→HLA-DMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF568 →	+6.044	+6.044	.001	.001	1	2
CNS	ZNF737 →	+4.459	+5.277	.005	.005	1	2
CNS	LY75-CD302 →	+4.459	+5.277	.005	.005	1	2
CNS	ANKRD34A →	+6.044	+6.044	.001	.001	1	2
LARGE_INTESTINE	TMEM150C →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	RGPD4 →	+2.865	+4.217	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 466 associations by consensus.

Exploration

HLA-DMA survival (RNA) · tumor vs normal (RNA) · all HLA-DMA data types