HLA-C

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HLA-C RNA expression is significantly associated with the protein abundance of many other proteins, with 12,361 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-C-associated proteins across cancer lineages are PSMB10, TRIM22, and PSMB5. Each is linked with HLA-C in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-C-to-partner and partner-to-HLA-C results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-C→partner) and Y-score (partner→HLA-C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCPSMB10 →+0.602+1.128<.001<.001310
HNSCTRIM22 →+0.575+0.983<.001<.001210
HNSCPSMB5 →-0.588-0.906<.001<.001210
LUADPSMB6 →-0.435-0.713<.001<.00139
OVPSMB9 →+0.547+0.988<.001<.00139
OVUBE2L6 →+0.713+1.499<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 12,361 associations by consensus.

Exploration