Across TCGA cell cohorts, HLA-C mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HLA-C-associated genes across cancer lineages are DEFA4 and TBC1D21. Each is linked with HLA-C in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-C-to-partner and partner-to-HLA-C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-C→partner) and Y-score (partner→HLA-C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

HLA-C survival (RNA) · tumor vs normal (RNA) · all HLA-C data types