HLA-A

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HLA-A RNA expression is significantly associated with the protein abundance of many other proteins, with 11,398 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-A-associated proteins across cancer lineages are PSMB5, PSMB6, and HLA-F. Each is linked with HLA-A in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-A-to-partner and partner-to-HLA-A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-A→partner) and Y-score (partner→HLA-A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVPSMB5 →-0.664-1.364<.001<.001310
COADPSMB6 →-0.552-0.852<.001<.001310
LSCCHLA-F →+0.667+0.778<.001<.00139
HNSCTRIM21 →+0.647+0.868<.001<.00139
HNSCTRIM22 →+0.626+0.941<.001<.00139
GBMPSMB10 →+0.689+0.921<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 11,398 associations by consensus.

Exploration