HLA-A

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HLA-A mutation is significantly associated with the RNA expression of many other genes, with 222 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-A-associated genes across cancer lineages are RNA5SP261, RNU2-38P, and FILNC1. Each is linked with HLA-A in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-A-to-partner and partner-to-HLA-A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-A→partner) and Y-score (partner→HLA-A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
DLBCRNA5SP261 →+0.453+5.491<.001.00232
HNSCRNU2-38P →+0.325+2.466<.001.00632
CESCFILNC1 →+0.281+3.819.007.00532
UCECRN7SL134P →+0.277+4.184<.001<.00132
UCECMIA-RAB4B →+0.122+3.863<.001<.00132
LUADRNA5SP426 →+0.358+6.599<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 222 associations by consensus.

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