HLA-A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HLA-A mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-A-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Tuberin_pT1462, and Chk1_pS345. Each is linked with HLA-A in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-A-to-partner and partner-to-HLA-A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-A→partner) and Y-score (partner→HLA-A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECGSK-3a-b_pS21_S9 →+0.691+3.009.005.01931
UCECTuberin_pT1462 →+0.415+3.009.001.01931
UCECChk1_pS345 →+0.174+3.013.029.01931
UCECMEK1 →+0.427+3.000.043.03721
UCECAkt_pT308 →+0.834+3.000.021.03721
UCECGATA3 →-0.264-2.986.015.03711
Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration