HKDC1

Across TCGA pan-cancer cohorts, HKDC1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HKDC1 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HKDC1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HKDC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, PAAD, and SARC are the cancer types where HKDC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.948	0.619	.005	28	view →
PAAD	OS	Median	All	0.132	0.590	<.001	12	view →
SARC	OS	Median	All	0.085	0.839	<.001	12	view →
LGG	DFS	Median	All	0.230	0.753	.005	12	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HKDC1–UCEC (DFS)

Open the UCEC breakdown →