HK3

Across TCGA pan-cancer cohorts, HK3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated HK3 data layer compared with 25 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HK3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HK3 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

BLCA, GBM, and READ are the cancer types where HK3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.087	0.599	<.001	16	view →
GBM	OS	Median	All	0.062	0.413	<.001	12	view →
READ	DFS	Median	All	0.240	0.745	.004	12	view →
LUSC	DFS	Median	III,IV	0.010	0.754	<.001	11	view →
SKCM	DFS	Median	All	0.136	0.769	<.001	9	view →
PAAD	OS	Median	All	0.131	0.640	.012	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	OS	Median	All	0.149	0.686	.047	3	view →
LUAD	OS	Median	All	0.364	0.675	.039	2	view →
COAD	OS	Median	All	1.000	0.520	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HK3–BLCA (DFS)

Open the BLCA breakdown →