HK3

Across TCGA pan-cancer cohorts, HK3 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HK3 data layer compared with 25 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HK3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HK3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, UCEC, and PDAC are the cancer types where HK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.882	1.000	.015	36	view →
UCEC	OS	Tertile	III,IV	1.000	0.326	.017	20	view →
PDAC	OS	Tertile	IV	0.231	0.916	.024	9	view →
GBM	OS	Tertile	All	0.256	0.542	.023	9	view →
LSCC	DFS	Quartile	All	0.815	0.265	.031	7	view →
LUAD	OS	Quartile	II,III,IV	0.870	1.000	.025	7	view →
CCRCC	DFS	Median	II,III,IV	0.451	1.000	.008	5	view →
HNSC	OS	Median	IV	0.935	0.734	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HK3–COAD (DFS)

Open the COAD breakdown →