HK3

Across TCGA patient cohorts, HK3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HK3-associated genes across cancer lineages are Cyclin-B1, GAPDH, and Caspase-7-cleavedD198. Each is linked with HK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both HK3-to-partner and partner-to-HK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HK3-low versus HK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HK3→partner) and Y-score (partner→HK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.387	+2.000	.026	.029	3	4
COAD	GAPDH →	+0.556	+2.820	.025	.035	3	3
COAD	Caspase-7-cleavedD198 →	+1.311	+3.000	<.001	.035	3	3
UCEC	Ku80 →	+0.161	+1.214	.028	.018	3	3
UCEC	Notch1 →	+0.165	+1.820	<.001	.001	3	3
UCEC	PCNA →	+0.153	+1.201	.022	.028	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Cyclin-B1 by HK3 expression — UCEC

Explore this box plot interactively →