HK3

Across TCGA cell cohorts, HK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,892 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HK3-associated GO terms across cancer lineages are Regulation of amino acid biosynthetic process, B cell mediated immunity, and Regulation of biological process involved in symbiotic interaction. Each is linked with HK3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HK3-to-partner and partner-to-HK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of amino acid biosynthetic process grouped by HK3-low versus HK3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HK3→partner) and Y-score (partner→HK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of amino acid biosynthetic process →	+0.153	+1.837	<.001	<.001	3	5
BREAST	B cell mediated immunity →	-0.061	-0.091	<.001	.001	3	4
OVARY	Regulation of biological process involved in symbiotic interaction →	+0.082	+0.064	<.001	.002	2	5
BLOOD_Leukemia	Positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential →	+0.876	+1.001	<.001	.004	3	4
BLOOD_Leukemia	Positive regulation of membrane repolarization during cardiac muscle cell action potential →	+0.876	+1.001	<.001	.004	3	4
BLOOD_Leukemia	Homologous chromosome segregation →	-0.060	-0.788	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,892 associations by consensus.

Regulation of amino acid biosynthetic process by HK3 expression — BLOOD_Leukemia

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