HK3

Across TCGA cell cohorts, HK3 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HK3-associated genes across cancer lineages are GUCA2A, MT1HL1, and PRR20B. Each is linked with HK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HK3-to-partner and partner-to-HK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by HK3-low versus HK3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HK3→partner) and Y-score (partner→HK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GUCA2A →	+0.067	+3.688	<.001	.002	3	3
LUNG_NSCLC_LUAD	MT1HL1 →	+0.065	+3.681	<.001	.009	3	2
BLOOD_Lymphoma	PRR20B →	+0.095	+4.058	<.001	.009	3	2
BLOOD_Lymphoma	PRR20A →	+0.095	+4.058	<.001	.009	3	2
BLOOD_Lymphoma	PRR20D →	+0.095	+4.058	<.001	.009	3	2
BLOOD_Lymphoma	PRR20E →	+0.095	+4.058	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

GUCA2A by HK3 expression — SKIN

Explore this box plot interactively →