HK2

Across TCGA pan-cancer cohorts, HK2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HK2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HK2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HK2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

LUAD, UCEC, and GBM are the cancer types where HK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.323	0.861	.003	29	view →
UCEC	OS	Quartile	III,IV	1.000	0.339	.024	20	view →
GBM	OS	Quartile	All	0.265	0.620	.008	20	view →
PDAC	DFS	Median	II,III,IV	0.292	0.524	.005	16	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.823	.011	6	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.904	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HK2–LUAD (OS)

Open the LUAD breakdown →