HK1

Across TCGA pan-cancer cohorts, HK1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HK1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where HK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.646	0.927	.001	41	view →
LUAD	DFS	Quartile	All	0.305	0.822	.004	27	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
HNSC	DFS	Median	III,IV	0.902	0.684	.005	8	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
UCEC	DFS	Median	III,IV	0.408	0.915	.015	4	view →
LSCC	DFS	Median	All	0.493	0.832	.035	3	view →
GBM	DFS	Tertile	All	0.855	0.656	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HK1–CCRCC (OS)

Open the CCRCC breakdown →