HK1

Across TCGA patient cohorts, HK1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HK1-associated genes across cancer lineages are ATM, Cyclin-E1, and eEF2. Each is linked with HK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HK1-to-partner and partner-to-HK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HK1-low versus HK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HK1→partner) and Y-score (partner→HK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.671	-2.201	<.001	<.001	3	3
COAD	Cyclin-E1 →	+0.263	+3.178	.033	.010	3	2
UCEC	eEF2 →	+0.384	+2.700	.001	.005	3	2
UCEC	eIF4E →	+0.227	+2.201	.001	<.001	3	2
UCEC	ERK2 →	+0.236	+3.807	<.001	<.001	3	2
UCEC	GAPDH →	+0.489	+2.321	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ATM by HK1 expression — UCEC

Explore this box plot interactively →