HJV

Across TCGA patient cohorts, HJV mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HJV-associated genes across cancer lineages are ATM, PKC-delta_pS664, and Annexin-1. Each is linked with HJV in more than 1 cancer types. Because this analysis shows association rather than direction, both HJV-to-partner and partner-to-HJV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HJV-low versus HJV-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HJV→partner) and Y-score (partner→HJV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.894	-2.986	<.001	.035	3	2
COAD	PKC-delta_pS664 →	-0.158	-2.991	.022	.036	3	1
UCEC	Annexin-1 →	+0.861	+2.827	.002	.035	3	1
SKCM	Bax →	-0.271	-2.459	.013	.020	3	1
COAD	PCNA →	+0.287	+3.008	.025	.019	1	2
COAD	4E-BP1 →	+0.284	+3.008	.012	.019	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by HJV expression — UCEC

Explore this box plot interactively →