HIVEP1

Across TCGA pan-cancer cohorts, HIVEP1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated HIVEP1 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher HIVEP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HIVEP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

THYM, UCEC, and STAD are the cancer types where HIVEP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	OS	Median	All	0.921	0.639	.010	26	view →
STAD	DFS	Median	All	0.900	0.643	.016	24	view →
ACC	DFS	Median	II,III,IV	0.046	0.732	<.001	21	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	6	view →
LAML	DFS	Median	All	0.112	0.582	.010	6	view →
LUSC	DFS	Median	All	0.710	0.355	.014	4	view →
PAAD	DFS	Median	All	0.149	0.508	.037	3	view →
BLCA	OS	Median	IV	0.272	0.601	.043	3	view →
CESC	DFS	Median	All	1.000	0.727	.049	2	view →
LGG	DFS	Median	All	1.000	0.383	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HIVEP1–THYM (OS)

Open the THYM breakdown →