HIVEP1

Across TCGA patient cohorts, HIVEP1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIVEP1-associated genes across cancer lineages are 4E-BP1, PI3K-p85, and Bad_pS112. Each is linked with HIVEP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HIVEP1-to-partner and partner-to-HIVEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HIVEP1-low versus HIVEP1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIVEP1→partner) and Y-score (partner→HIVEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.272	+3.169	.025	.018	3	4
SKCM	PI3K-p85 →	+0.120	+1.584	.046	.001	3	3
UCEC	Bad_pS112 →	-0.124	-1.723	.010	.005	3	3
BLCA	MSH6 →	-0.287	-1.773	.046	.026	3	2
BLCA	Bim →	-0.218	-2.304	.041	.006	3	2
STAD	PCNA →	+0.312	+3.321	.007	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

4E-BP1 by HIVEP1 expression — STAD

Explore this box plot interactively →