HIPK4

Across TCGA pan-cancer cohorts, HIPK4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HIPK4 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HIPK4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HIPK4 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

HNSC, OV, and SKCM are the cancer types where HIPK4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.177	0.710	.016	6	view →
OV	DFS	Median	II,III,IV	1.000	0.376	.036	4	view →
SKCM	OS	Median	III,IV	0.232	0.697	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HIPK4–HNSC (OS)

Open the HNSC breakdown →