HIPK2

Across TCGA patient cohorts, HIPK2 mutation is significantly associated with the RNA expression of many other genes, with 4,625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIPK2-associated genes across cancer lineages are H2AZ1, MAD2L1, and MTHFD2. Each is linked with HIPK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HIPK2-to-partner and partner-to-HIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AZ1 grouped by HIPK2-low versus HIPK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK2→partner) and Y-score (partner→HIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AZ1 →	+0.563	+2.401	<.001	<.001	3	4
UCEC	MAD2L1 →	+0.697	+2.120	<.001	<.001	3	4
COAD	MTHFD2 →	+0.631	+3.700	<.001	.001	3	4
COAD	EIF5AL1 →	+1.072	+2.727	<.001	.003	3	4
UCEC	BCAS2 →	+0.447	+3.917	<.001	<.001	3	4
LUSC	MND1 →	+0.812	+3.345	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,625 associations by consensus.

H2AZ1 by HIPK2 expression — UCEC

Explore this box plot interactively →