HIPK2

Across TCGA cell cohorts, HIPK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,557 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HIPK2-associated GO terms across cancer lineages are Peptidyl-serine phosphorylation, Peptidyl-serine modification, and PML body organization. Each is linked with HIPK2 in more than 13 cancer types. Because this analysis shows association rather than direction, both HIPK2-to-partner and partner-to-HIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-serine phosphorylation grouped by HIPK2-low versus HIPK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK2→partner) and Y-score (partner→HIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Peptidyl-serine phosphorylation →	+0.066	+1.188	<.001	<.001	3	13
LUNG_SCLC	Peptidyl-serine modification →	+0.072	+0.970	.001	.004	2	14
LIVER	PML body organization →	+0.234	+1.726	<.001	.003	3	13
UPPER_AERODIGESTIVE_TRACT	Embryonic retina morphogenesis in camera-type eye →	+0.863	+1.060	<.001	<.001	3	13
BONE	SMAD protein signal transduction →	+0.144	+1.133	<.001	.002	3	13
BONE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.065	+1.223	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,557 associations by consensus.

Peptidyl-serine phosphorylation by HIPK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →