HIPK2

Across TCGA cell cohorts, HIPK2 mutation is significantly associated with the RNA expression of many other genes, with 1,322 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIPK2-associated genes across cancer lineages are RFC5, GEMIN4, and ANKRD34C. Each is linked with HIPK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HIPK2-to-partner and partner-to-HIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC5 grouped by HIPK2-low versus HIPK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK2→partner) and Y-score (partner→HIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RFC5 →	+0.772	+3.214	<.001	.006	3	3
LARGE_INTESTINE	GEMIN4 →	+0.728	+2.743	<.001	.001	3	3
BLOOD_Leukemia	ANKRD34C →	+0.230	+2.744	<.001	.001	3	2
BLOOD_Leukemia	C12orf57 →	+1.122	+3.489	.001	.001	3	2
LARGE_INTESTINE	UST →	+1.816	+3.850	<.001	<.001	3	2
BLOOD_Leukemia	DESI2 →	+0.725	+3.489	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,322 associations by consensus.

RFC5 by HIPK2 expression — BLOOD_Leukemia

Explore this box plot interactively →