HIPK2

Across TCGA cell cohorts, HIPK2 mutation is significantly associated with the mutation status of many other genes, with 6,633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIPK2-associated genes across cancer lineages are PER1, CEP250, and ZNF618. Each is linked with HIPK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HIPK2-to-partner and partner-to-HIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PER1 grouped by HIPK2-low versus HIPK2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK2→partner) and Y-score (partner→HIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PER1 →	+3.718	+3.053	.006	.006	1	5
LARGE_INTESTINE	CEP250 →	+3.129	+2.787	<.001	<.001	1	5
BLOOD_Leukemia	ZNF618 →	+2.256	+2.071	.009	.009	1	5
LARGE_INTESTINE	ZNF496 →	+3.222	+2.471	<.001	<.001	1	5
BONE	SCRIB →	+5.000	+4.437	.007	.007	1	4
BREAST	GBF1 →	+4.297	+4.857	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,633 associations by consensus.

PER1 by HIPK2 expression — SKIN

Explore this box plot interactively →