HIPK1

Across TCGA pan-cancer cohorts, HIPK1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HIPK1 data layer compared with 25 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HIPK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIPK1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC and LSCC are the cancer types where HIPK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.256	0.500	.030	5	view →
LSCC	DFS	Quartile	All	1.000	0.260	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HIPK1–PDAC (DFS)

Open the PDAC breakdown →