HIPK1

Across TCGA patient cohorts, HIPK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,331 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HIPK1-associated proteins across cancer lineages are TRIM33, TRIM33_S1119, and BBS2. Each is linked with HIPK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HIPK1-to-partner and partner-to-HIPK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIPK1 versus TRIM33 in LSCC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK1→partner) and Y-score (partner→HIPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM33 →	+0.282	+0.350	<.001	<.001	3	4
PDAC	TRIM33_S1119 →	+0.711	+0.281	<.001	.001	3	4
BRCA	BBS2 →	+0.402	+0.538	.002	.004	3	4
BRCA	MTHFD2 →	-0.637	-0.764	<.001	<.001	3	3
GBM	NUCB1_T148 →	-0.359	-0.220	.001	.001	3	3
BRCA	RACK1 →	-0.155	-0.630	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,331 associations by consensus.

HIPK1 vs TRIM33 — LSCC

Explore this scatter interactively →