HIPK1

Across TCGA patient cohorts, HIPK1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIPK1-associated genes across cancer lineages are FoxM1, Notch1, and Src_pY527. Each is linked with HIPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIPK1-to-partner and partner-to-HIPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by HIPK1-low versus HIPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK1→partner) and Y-score (partner→HIPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.194	+1.459	.005	.001	3	2
UCEC	Notch1 →	+0.139	+1.483	<.001	.003	3	2
UCEC	Src_pY527 →	-0.229	-1.237	.048	.041	3	2
COAD	ASNS →	+0.812	+2.815	<.001	.036	3	2
UCEC	ATM →	-0.510	-2.446	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.236	-2.295	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

FoxM1 by HIPK1 expression — UCEC

Explore this box plot interactively →